Symbol: Name: ID: |
BYSL bystin-like GFS:1421 |
Gene name: | BYSL |
Chromosome: | 6p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1858419 | Rat Genome Database ID: | RGD:727959 |
HGNC ID: | HGNC:1157 | RefSeq IDs: | NM_004053 |
Entrez Gene ID: | 705 | Ensembl Gene ID: | ENSG00000112578 |
VEGA IDs: | OTTHUMG00000014687 | UniProt ID: | Q13895 |
UCSC ID: | uc003orl.2 | OMIM ID: | 603871 |
Pubmed: | PMID9925933 PMID 17381424 | ||
CCDS IDs: | CCDSCCDS34450.1 |
Bystin is a protein that in humans is encoded by the BYSL gene. Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.
Products for BYSL gene
Catalog | Product Name | Application | Company |
GFS:E01421 | bystin-like; ELISA kit | ELISA | n/a |
GFS:A01421 | bystin-like; Anti | ANTIBODIES | n/a |
GFS:P01421 | bystin-like; Protien | Protien | n/a |