Symbol: Name: ID: |
BIN1 bridging integrator 1 GFS:459 |
Gene name: | BIN1 |
Chromosome: | 2q14 |
Previous Symbols: | AMPHL |
Previous Names: | |
Aliases: | SH3P9, AMPH2 |
Name Aliases: | amphiphysin II |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108092 | Rat Genome Database ID: | RGD:621786 |
HGNC ID: | HGNC:1052 | RefSeq IDs: | NM_004305 |
Entrez Gene ID: | 274 | Ensembl Gene ID: | ENSG00000136717 |
VEGA IDs: | OTTHUMG00000131465 | UniProt ID: | O00499 |
UCSC ID: | uc002tns.1 | OMIM ID: | 601248 |
Pubmed: | PMID8725406 PMID 8782822 PMID 17676042 | ||
CCDS IDs: | CCDSCCDS2137.1 CCDS CCDS2138.1 CCDS CCDS2139.1 CCDS CCDS2140.1 CCDS CCDS2141.1 CCDS CCDS2142.1 CCDS CCDS2143.1 CCDS CCDS42743.1 CCDS CCDS42744.1 CCDS CCDS46403.1 |
BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq].
Products for BIN1 gene
Catalog | Product Name | Application | Company |
GFS:E00459 | bridging integrator 1; ELISA kit | ELISA | n/a |
GFS:A00459 | bridging integrator 1; Anti | ANTIBODIES | n/a |
GFS:P00459 | bridging integrator 1; Protien | Protien | n/a |