Symbol: Name: ID: |
BRMS1 breast cancer metastasis suppressor 1 GFS:6343 |
Gene name: | BRMS1 |
Chromosome: | 11q13-q13.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DKFZP564A063 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2388804 | Rat Genome Database ID: | RGD:1311057 |
HGNC ID: | HGNC:17262 | RefSeq IDs: | NM_001024957 |
Entrez Gene ID: | 25855 | Ensembl Gene ID: | ENSG00000174744 |
VEGA IDs: | UniProt ID: | Q9HCU9 | |
UCSC ID: | uc001oho.1 | OMIM ID: | 606259 |
Pubmed: | PMID10850410 | ||
CCDS IDs: | CCDSCCDS8135.1 CCDS CCDS44654.1 |
Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Products for BRMS1 gene
Catalog | Product Name | Application | Company |
GFS:E06343 | breast cancer metastasis suppressor 1; ELISA kit | ELISA | n/a |
GFS:A06343 | breast cancer metastasis suppressor 1; Anti | ANTIBODIES | n/a |
GFS:P06343 | breast cancer metastasis suppressor 1; Protien | Protien | n/a |