Symbol: Name: ID: |
BRCA2 breast cancer 2, early onset GFS:919 |
Gene name: | BRCA2 |
Chromosome: | 13q12-q13 |
Previous Symbols: | FANCD1, FACD, FANCD |
Previous Names: | Fanconi anemia, complementation group D1 |
Aliases: | FAD, FAD1, BRCC2 |
Name Aliases: | BRCA1/BRCA2-containing complex, subunit 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109337 | Rat Genome Database ID: | RGD:2219 |
HGNC ID: | HGNC:1101 | RefSeq IDs: | NM_000059 |
Entrez Gene ID: | 675 | Ensembl Gene ID: | ENSG00000139618 |
VEGA IDs: | OTTHUMG00000017411 | UniProt ID: | P51587 |
UCSC ID: | uc001uub.1 | OMIM ID: | 600185 |
Pubmed: | PMID8091231 PMID 7581463 | ||
CCDS IDs: | CCDSCCDS9344.1 |
BRCA2 (Breast Cancer 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene. Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures
Products for BRCA2 gene
Catalog | Product Name | Application | Company |
GFS:E00919 | breast cancer 2, early onset; ELISA kit | ELISA | n/a |
GFS:A00919 | breast cancer 2, early onset; Anti | ANTIBODIES | n/a |
GFS:P00919 | breast cancer 2, early onset; Protien | Protien | n/a |