Symbol: Name: ID: |
BDNF brain-derived neurotrophic factor GFS:284 |
Gene name: | BDNF |
Chromosome: | 11p14.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | neurotrophin |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88145 | Rat Genome Database ID: | RGD:2202 |
HGNC ID: | HGNC:1033 | RefSeq IDs: | NM_001143805 |
Entrez Gene ID: | 627 | Ensembl Gene ID: | ENSG00000176697 |
VEGA IDs: | UniProt ID: | P23560 | |
UCSC ID: | uc001mrm.2 | OMIM ID: | 113505 |
Pubmed: | PMID2236018 PMID 1889806 PMID 17942328 PMID 17493809 | ||
CCDS IDs: | CCDSCCDS7865.1 CCDS CCDS7866.1 CCDS CCDS44558.1 |
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. (provided by RefSeq)
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability
Products for BDNF gene
Catalog | Product Name | Application | Company |
GFS:E00284 | brain-derived neurotrophic factor; ELISA kit | ELISA | n/a |
GFS:A00284 | brain-derived neurotrophic factor; Anti | ANTIBODIES | n/a |
GFS:P00284 | brain-derived neurotrophic factor; Protien | Protien | n/a |