Symbol: Name: ID: |
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) GFS:972 |
Gene name: | BRE |
Chromosome: | 2p23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BRCC45, BRCC4 |
Name Aliases: | BRCA1/BRCA2-containing complex, subunit 4 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333875 | Rat Genome Database ID: | RGD:735111 |
HGNC ID: | HGNC:1106 | RefSeq IDs: | NM_004899 |
Entrez Gene ID: | 9577 | Ensembl Gene ID: | ENSG00000158019 |
VEGA IDs: | OTTHUMG00000097831 | UniProt ID: | Q9NXR7 |
UCSC ID: | uc002rls.2 | OMIM ID: | 610497 |
Pubmed: | PMID9737713 PMID 7826398 | ||
CCDS IDs: | CCDSCCDS1763.1 CCDS CCDS1764.1 CCDS CCDS1765.1 |
BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
Products for BRE gene
Catalog | Product Name | Application | Company |
GFS:E00972 | brain and reproductive organ-expressed (TNFRSF1A modulator); ELISA kit | ELISA | n/a |
GFS:A00972 | brain and reproductive organ-expressed (TNFRSF1A modulator); Anti | ANTIBODIES | n/a |
GFS:P00972 | brain and reproductive organ-expressed (TNFRSF1A modulator); Protien | Protien | n/a |