Symbol: Name: ID: |
BTRC beta-transducin repeat containing GFS:1310 |
Gene name: | BTRC |
Chromosome: | 10q24.32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | bTrCP, betaTrCP, FBXW1A, Fwd1, beta-TrCP1, bTrCP1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1338871 | Rat Genome Database ID: | RGD:1359721 |
HGNC ID: | HGNC:1144 | RefSeq IDs: | NM_003939 |
Entrez Gene ID: | 8945 | Ensembl Gene ID: | ENSG00000166167 |
VEGA IDs: | OTTHUMG00000018932 | UniProt ID: | Q9Y297 |
UCSC ID: | uc001kta.2 | OMIM ID: | 603482 |
Pubmed: | PMID9660940 PMID 10331953 PMID 18354483 | ||
CCDS IDs: | CCDSCCDS7511.1 CCDS CCDS7512.1 |
The F-box/WD repeat-containing protein 1A also known as pIkappaBalpha-E3 receptor subunit is a protein that in humans is encoded by the BTRC (beta-transducin repeat containing) gene. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq].
Products for BTRC gene
Catalog | Product Name | Application | Company |
GFS:E01310 | beta-transducin repeat containing; ELISA kit | ELISA | n/a |
GFS:A01310 | beta-transducin repeat containing; Anti | ANTIBODIES | n/a |
GFS:P01310 | beta-transducin repeat containing; Protien | Protien | n/a |