Symbol: Name: ID: |
BHLHE22 basic helix-loop-helix family, member e22 GFS:1772 |
Gene name: | BHLHE22 |
Chromosome: | 8q12.1 |
Previous Symbols: | TNRC20, BHLHB5 |
Previous Names: | trinucleotide repeat containing 20, "basic helix-loop-helix domain containing, class B, 5" |
Aliases: | CAGL85, Beta3, bHLHe22 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930001 | Rat Genome Database ID: | RGD:1305451 |
HGNC ID: | HGNC:11963 | RefSeq IDs: | NM_152414 |
Entrez Gene ID: | 27319 | Ensembl Gene ID: | ENSG00000180828 |
VEGA IDs: | UniProt ID: | Q8NFJ8 | |
UCSC ID: | uc003xvi.2 | OMIM ID: | 613483 |
Pubmed: | PMID9225980 PMID 12213201 PMID 18557763 | ||
CCDS IDs: | CCDSCCDS6179.1 |
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM].
Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity).
Products for BHLHE22 gene
Catalog | Product Name | Application | Company |
GFS:E01772 | basic helix-loop-helix family, member e22; ELISA kit | ELISA | n/a |
GFS:A01772 | basic helix-loop-helix family, member e22; Anti | ANTIBODIES | n/a |
GFS:P01772 | basic helix-loop-helix family, member e22; Protien | Protien | n/a |