Symbol: Name: ID: |
BANF1 barrier to autointegration factor 1 GFS:6467 |
Gene name: | BANF1 |
Chromosome: | 11q13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BAF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1346330 | Rat Genome Database ID: | RGD:620662 |
HGNC ID: | HGNC:17397 | RefSeq IDs: | NM_001143985 |
Entrez Gene ID: | 8815 | Ensembl Gene ID: | ENSG00000175334 |
VEGA IDs: | UniProt ID: | O75531 | |
UCSC ID: | uc001ogp.2 | OMIM ID: | 603811 |
Pubmed: | PMID9465049 | ||
CCDS IDs: | CCDSCCDS8125.1 |
Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene.
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009].
Function: Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
Products for BANF1 gene
Catalog | Product Name | Application | Company |
GFS:E06467 | barrier to autointegration factor 1; ELISA kit | ELISA | n/a |
GFS:A06467 | barrier to autointegration factor 1; Anti | ANTIBODIES | n/a |
GFS:P06467 | barrier to autointegration factor 1; Protien | Protien | n/a |