Symbol: Name: ID: |
BIRC7 baculoviral IAP repeat containing 7 GFS:3213 |
Gene name: | BIRC7 |
Chromosome: | 20q13.3 |
Previous Symbols: | |
Previous Names: | baculoviral IAP repeat-containing 7 |
Aliases: | mliap, ML-IAP, KIAP, RNF50 |
Name Aliases: | melanoma inhibitor of apoptosis protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2676458 | Rat Genome Database ID: | RGD:1562883 |
HGNC ID: | HGNC:13702 | RefSeq IDs: | NM_022161 |
Entrez Gene ID: | 79444 | Ensembl Gene ID: | ENSG00000101197 |
VEGA IDs: | OTTHUMG00000032957 | UniProt ID: | Q96CA5 |
UCSC ID: | uc002yej.2 | OMIM ID: | 605737 |
Pubmed: | PMID11024045 PMID 11162435 | ||
CCDS IDs: | CCDSCCDS13512.1 CCDS CCDS13513.1 |
Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq, Jul 2008].
Function: Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
Products for BIRC7 gene
Catalog | Product Name | Application | Company |
GFS:E03213 | baculoviral IAP repeat containing 7; ELISA kit | ELISA | n/a |
GFS:A03213 | baculoviral IAP repeat containing 7; Anti | ANTIBODIES | n/a |
GFS:P03213 | baculoviral IAP repeat containing 7; Protien | Protien | n/a |