Symbol: Name: ID: |
ASPN asporin GFS:4160 |
Gene name: | ASPN |
Chromosome: | 9q22.31 |
Previous Symbols: | |
Previous Names: | asporin (LRR class 1) |
Aliases: | FLJ20129, SLRR1C, PLAP1 |
Name Aliases: | asporin proteoglycan |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913945 | Rat Genome Database ID: | RGD:1549776 |
HGNC ID: | HGNC:14872 | RefSeq IDs: | NM_001193335 |
Entrez Gene ID: | 54829 | Ensembl Gene ID: | ENSG00000106819 |
VEGA IDs: | OTTHUMG00000020227 | UniProt ID: | Q9BXN1 |
UCSC ID: | uc004ase.1 | OMIM ID: | 608135 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS6697.1 |
Asporin is a protein that in humans is encoded by the ASPN gene.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
Function: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to the BMP receptor-IB (BMPR-IB), resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Products for ASPN gene
Catalog | Product Name | Application | Company |
GFS:E04160 | asporin; ELISA kit | ELISA | n/a |
GFS:A04160 | asporin; Anti | ANTIBODIES | n/a |
GFS:P04160 | asporin; Protien | Protien | n/a |