Symbol: Name: ID: |
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 GFS:7787 |
Gene name: | ARNTL2 |
Chromosome: | 12p12.2-p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BMAL2, MOP9, CLIF, PASD9, bHLHe6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2684845 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18984 | RefSeq IDs: | NM_020183 |
Entrez Gene ID: | 56938 | Ensembl Gene ID: | ENSG00000029153 |
VEGA IDs: | UniProt ID: | Q8WYA1 | |
UCSC ID: | uc001rht.1 | OMIM ID: | |
Pubmed: | PMID10864977 PMID 10964693 | ||
CCDS IDs: | CCDSCCDS8712.1 |
Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9, Bmal2, CLIF or ARNTL2, is a gene.
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Function: ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1.
Products for ARNTL2 gene
Catalog | Product Name | Application | Company |
GFS:E07787 | aryl hydrocarbon receptor nuclear translocator-like 2; ELISA kit | ELISA | n/a |
GFS:A07787 | aryl hydrocarbon receptor nuclear translocator-like 2; Anti | ANTIBODIES | n/a |
GFS:P07787 | aryl hydrocarbon receptor nuclear translocator-like 2; Protien | Protien | n/a |