Symbol: Name: ID: |
AANAT aralkylamine N-acetyltransferase GFS:7801 |
Gene name: | AANAT |
Chromosome: | 17q25 |
Previous Symbols: | |
Previous Names: | arylalkylamine N-acetyltransferase |
Aliases: | SNAT |
Name Aliases: | serotonin N-acetyltransferase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1328365 | Rat Genome Database ID: | RGD:2006 |
HGNC ID: | HGNC:19 | RefSeq IDs: | NM_001088 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000129673 | |
VEGA IDs: | UniProt ID: | Q16613 | |
UCSC ID: | uc002jro.2 | OMIM ID: | 600950 |
Pubmed: | PMID8661026 | ||
CCDS IDs: | CCDSCCDS11745.1 |
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Function: Catalyzes the N-acetylation of serotonin into N-acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines.
Products for AANAT gene
Catalog | Product Name | Application | Company |
GFS:E07801 | aralkylamine N-acetyltransferase; ELISA kit | ELISA | n/a |
GFS:A07801 | aralkylamine N-acetyltransferase; Anti | ANTIBODIES | n/a |
GFS:P07801 | aralkylamine N-acetyltransferase; Protien | Protien | n/a |