Symbol: Name: ID: |
ALOXE3 arachidonate lipoxygenase 3 GFS:3248 |
Gene name: | ALOXE3 |
Chromosome: | 17p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | eLOX3, E-LOX |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345140 | Rat Genome Database ID: | RGD:1306252 |
HGNC ID: | HGNC:13743 | RefSeq IDs: | NM_001165960 |
Entrez Gene ID: | 59344 | Ensembl Gene ID: | ENSG00000179148 |
VEGA IDs: | OTTHUMG00000108179 | UniProt ID: | Q9BYJ1 |
UCSC ID: | uc010cnr.2 | OMIM ID: | 607206 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS11130.1 |
Epidermis-type lipoxygenase 3 is an enzyme that in humans is encoded by the ALOXE3 gene.
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Function: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
Products for ALOXE3 gene
Catalog | Product Name | Application | Company |
GFS:E03248 | arachidonate lipoxygenase 3; ELISA kit | ELISA | n/a |
GFS:A03248 | arachidonate lipoxygenase 3; Anti | ANTIBODIES | n/a |
GFS:P03248 | arachidonate lipoxygenase 3; Protien | Protien | n/a |