Symbol: Name: ID: |
ACIN1 apoptotic chromatin condensation inducer 1 GFS:6159 |
Gene name: | ACIN1 |
Chromosome: | 14q11.2 |
Previous Symbols: | ACINUS |
Previous Names: | apoptotic chromatin condensation inducer in the nucleus |
Aliases: | KIAA0670, fSAP152 |
Name Aliases: | functional spliceosome-associated protein 152 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891824 | Rat Genome Database ID: | RGD:1311945 |
HGNC ID: | HGNC:17066 | RefSeq IDs: | NM_001164814 |
Entrez Gene ID: | 22985 | Ensembl Gene ID: | ENSG00000100813 |
VEGA IDs: | OTTHUMG00000028716 | UniProt ID: | Q9UKV3 |
UCSC ID: | uc001wit.3 | OMIM ID: | 604562 |
Pubmed: | PMID9734811 PMID 10490026 | ||
CCDS IDs: | CCDSCCDS9587.1 |
Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
Products for ACIN1 gene
Catalog | Product Name | Application | Company |
GFS:E06159 | apoptotic chromatin condensation inducer 1; ELISA kit | ELISA | n/a |
GFS:A06159 | apoptotic chromatin condensation inducer 1; Anti | ANTIBODIES | n/a |
GFS:P06159 | apoptotic chromatin condensation inducer 1; Protien | Protien | n/a |