Symbol: Name: ID: |
APLN apelin GFS:5766 |
Gene name: | APLN |
Chromosome: | Xq25 |
Previous Symbols: | |
Previous Names: | apelin, AGTRL1 ligand |
Aliases: | apelin, XNPEP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353624 | Rat Genome Database ID: | RGD:620672 |
HGNC ID: | HGNC:16665 | RefSeq IDs: | NM_017413 |
Entrez Gene ID: | 8862 | Ensembl Gene ID: | ENSG00000171388 |
VEGA IDs: | OTTHUMG00000022371 | UniProt ID: | Q9ULZ1 |
UCSC ID: | uc004eus.2 | OMIM ID: | 300297 |
Pubmed: | PMID9792798 PMID 10525157 | ||
CCDS IDs: | CCDSCCDS48165.1 |
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.
Products for APLN gene
Catalog | Product Name | Application | Company |
GFS:E05766 | apelin; ELISA kit | ELISA | n/a |
GFS:A05766 | apelin; Anti | ANTIBODIES | n/a |
GFS:P05766 | apelin; Protien | Protien | n/a |