Symbol: Name: ID: |
AGTRAP angiotensin II receptor-associated protein GFS:3092 |
Gene name: | AGTRAP |
Chromosome: | 1p36.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ATRAP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1339977 | Rat Genome Database ID: | RGD:1359346 |
HGNC ID: | HGNC:13539 | RefSeq IDs: | NM_001040194 |
Entrez Gene ID: | 57085 | Ensembl Gene ID: | ENSG00000177674 |
VEGA IDs: | OTTHUMG00000002230 | UniProt ID: | Q6RW13 |
UCSC ID: | uc001asv.2 | OMIM ID: | 608729 |
Pubmed: | PMID11733189 | ||
CCDS IDs: | CCDSCCDS136.1 CCDS CCDS30585.1 CCDS CCDS30586.1 CCDS CCDS41248.1 CCDS CCDS44056.1 |
Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Products for AGTRAP gene
Catalog | Product Name | Application | Company |
GFS:E03092 | angiotensin II receptor-associated protein; ELISA kit | ELISA | n/a |
GFS:A03092 | angiotensin II receptor-associated protein; Anti | ANTIBODIES | n/a |
GFS:P03092 | angiotensin II receptor-associated protein; Protien | Protien | n/a |