Symbol: Name: ID: |
ANGPTL4 angiopoietin-like 4 GFS:5166 |
Gene name: | ANGPTL4 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | pp1158, PGAR, ARP4, HFARP, FIAF, NL2 |
Name Aliases: | fasting-induced adipose factor, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888999 | Rat Genome Database ID: | RGD:735058 |
HGNC ID: | HGNC:16039 | RefSeq IDs: | NM_001039667 |
Entrez Gene ID: | 51129 | Ensembl Gene ID: | ENSG00000167772 |
VEGA IDs: | UniProt ID: | Q9BY76 | |
UCSC ID: | uc002mjq.1 | OMIM ID: | 605910 |
Pubmed: | PMID10698685 PMID 10866690 | ||
CCDS IDs: | CCDSCCDS12200.1 CCDS CCDS42493.1 |
Angiopoietin-related protein 4 is a protein that in humans is encoded by the ANGPTL4 gene.
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Jul 2008].
Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
Products for ANGPTL4 gene
Catalog | Product Name | Application | Company |
GFS:E05166 | angiopoietin-like 4; ELISA kit | ELISA | n/a |
GFS:A05166 | angiopoietin-like 4; Anti | ANTIBODIES | n/a |
GFS:P05166 | angiopoietin-like 4; Protien | Protien | n/a |