Symbol: Name: ID: |
AMOT angiomotin GFS:6713 |
Gene name: | AMOT |
Chromosome: | Xq23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1071 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108440 | Rat Genome Database ID: | RGD:1564027 |
HGNC ID: | HGNC:17810 | RefSeq IDs: | NM_001113490 |
Entrez Gene ID: | 154796 | Ensembl Gene ID: | ENSG00000126016 |
VEGA IDs: | OTTHUMG00000022216 | UniProt ID: | Q4VCS5 |
UCSC ID: | uc004epr.2 | OMIM ID: | 300410 |
Pubmed: | PMID11257124 PMID 16043488 PMID 12406577 | ||
CCDS IDs: | CCDSCCDS14563.1 CCDS CCDS48154.1 |
Angiomotin is a protein that in humans is encoded by the AMOT gene.
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
Products for AMOT gene
Catalog | Product Name | Application | Company |
GFS:E06713 | angiomotin; ELISA kit | ELISA | n/a |
GFS:A06713 | angiomotin; Anti | ANTIBODIES | n/a |
GFS:P06713 | angiomotin; Protien | Protien | n/a |