Symbol: Name: ID: |
AADAT aminoadipate aminotransferase GFS:6827 |
Gene name: | AADAT |
Chromosome: | 4q33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KATII, KAT2 |
Name Aliases: | kynurenine aminotransferase II, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345167 | Rat Genome Database ID: | RGD:2948 |
HGNC ID: | HGNC:17929 | RefSeq IDs: | NM_016228 |
Entrez Gene ID: | 51166 | Ensembl Gene ID: | ENSG00000109576 |
VEGA IDs: | OTTHUMG00000160912 | UniProt ID: | Q8N5Z0 |
UCSC ID: | uc003isr.2 | OMIM ID: | 611754 |
Pubmed: | PMID12126930 PMID 10441733 | ||
CCDS IDs: | CCDSCCDS3814.1 |
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008].
Function: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Products for AADAT gene
Catalog | Product Name | Application | Company |
GFS:E06827 | aminoadipate aminotransferase; ELISA kit | ELISA | n/a |
GFS:A06827 | aminoadipate aminotransferase; Anti | ANTIBODIES | n/a |
GFS:P06827 | aminoadipate aminotransferase; Protien | Protien | n/a |