Symbol: Name: ID: |
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 GFS:570 |
Gene name: | AIMP1 |
Chromosome: | 4q24 |
Previous Symbols: | SCYE1 |
Previous Names: | small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) |
Aliases: | EMAPII, EMAP-2, p43 |
Name Aliases: | EMAP II, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102774 | Rat Genome Database ID: | RGD:620466 |
HGNC ID: | HGNC:10648 | RefSeq IDs: | NM_001142415 |
Entrez Gene ID: | 9255 | Ensembl Gene ID: | ENSG00000164022 |
VEGA IDs: | OTTHUMG00000131217 | UniProt ID: | Q12904 |
UCSC ID: | uc003hyh.2 | OMIM ID: | 603605 |
Pubmed: | PMID7929199 PMID 7545917 | ||
CCDS IDs: | CCDSCCDS3674.1 CCDS CCDS47121.1 |
The protein encoded by AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq].
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7
Products for AIMP1 gene
Catalog | Product Name | Application | Company |
GFS:E00570 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; ELISA kit | ELISA | n/a |
GFS:A00570 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; Anti | ANTIBODIES | n/a |
GFS:P00570 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; Protien | Protien | n/a |