Symbol: Name: ID: |
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) GFS:6812 |
Gene name: | ALKBH1 |
Chromosome: | 14q24 |
Previous Symbols: | ALKBH |
Previous Names: | alkB, alkylation repair homolog (E. coli) |
Aliases: | hABH, alkB, ABH |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384034 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17911 | RefSeq IDs: | NM_006020 |
Entrez Gene ID: | 8846 | Ensembl Gene ID: | ENSG00000100601 |
VEGA IDs: | UniProt ID: | Q13686 | |
UCSC ID: | uc001xuc.1 | OMIM ID: | 605345 |
Pubmed: | PMID8600462 | ||
CCDS IDs: | CCDSCCDS32127.1 |
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008].
Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
Products for ALKBH1 gene
Catalog | Product Name | Application | Company |
GFS:E06812 | alkB, alkylation repair homolog 1 (E. coli); ELISA kit | ELISA | n/a |
GFS:A06812 | alkB, alkylation repair homolog 1 (E. coli); Anti | ANTIBODIES | n/a |
GFS:P06812 | alkB, alkylation repair homolog 1 (E. coli); Protien | Protien | n/a |