Symbol: Name: ID: |
ADHFE1 alcohol dehydrogenase, iron containing, 1 GFS:5474 |
Gene name: | ADHFE1 |
Chromosome: | 8q12.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ADHFe1, FLJ32430 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1923437 | Rat Genome Database ID: | RGD:1308863 |
HGNC ID: | HGNC:16354 | RefSeq IDs: | NM_144650 |
Entrez Gene ID: | 137872 | Ensembl Gene ID: | ENSG00000147576 |
VEGA IDs: | OTTHUMG00000150215 | UniProt ID: | Q8IWW8 |
UCSC ID: | uc003xwb.3 | OMIM ID: | 611083 |
Pubmed: | PMID12592711 | ||
CCDS IDs: | CCDSCCDS6190.2 |
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008].
Function: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
Products for ADHFE1 gene
Catalog | Product Name | Application | Company |
GFS:E05474 | alcohol dehydrogenase, iron containing, 1; ELISA kit | ELISA | n/a |
GFS:A05474 | alcohol dehydrogenase, iron containing, 1; Anti | ANTIBODIES | n/a |
GFS:P05474 | alcohol dehydrogenase, iron containing, 1; Protien | Protien | n/a |