Symbol: Name: ID: |
APCDD1 adenomatosis polyposis coli down-regulated 1 GFS:4880 |
Gene name: | APCDD1 |
Chromosome: | 18p11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | B7323 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3513977 | Rat Genome Database ID: | RGD:1589962 |
HGNC ID: | HGNC:15718 | RefSeq IDs: | NM_153000 |
Entrez Gene ID: | 147495 | Ensembl Gene ID: | ENSG00000154856 |
VEGA IDs: | OTTHUMG00000131635 | UniProt ID: | Q8J025 |
UCSC ID: | uc002kom.3 | OMIM ID: | 607479 |
Pubmed: | PMID12384519 | ||
CCDS IDs: | CCDSCCDS11849.1 |
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010].
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Products for APCDD1 gene
Catalog | Product Name | Application | Company |
GFS:E04880 | adenomatosis polyposis coli down-regulated 1; ELISA kit | ELISA | n/a |
GFS:A04880 | adenomatosis polyposis coli down-regulated 1; Anti | ANTIBODIES | n/a |
GFS:P04880 | adenomatosis polyposis coli down-regulated 1; Protien | Protien | n/a |