Acetyl-coenzyme A synthetase, cytoplasmic is an enzyme that in humans is encoded by the ACSS2 gene.

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].
Function: Activates acetate so that it can be used for lipid synthesis or for energy generation.