Symbol: Name: ID: |
ACHE acetylcholinesterase GFS:715 |
Gene name: | ACHE |
Chromosome: | 7q22 |
Previous Symbols: | YT |
Previous Names: | acetylcholinesterase (YT blood group), "acetylcholinesterase (Yt blood group)" |
Aliases: | |
Name Aliases: | Yt blood group |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:87876 | Rat Genome Database ID: | RGD:69313 |
HGNC ID: | HGNC:108 | RefSeq IDs: | NM_000665 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000087085 | |
VEGA IDs: | OTTHUMG00000157033 | UniProt ID: | P22303 |
UCSC ID: | uc003uxe.2 | OMIM ID: | 100740 |
Pubmed: | PMID1380483 | ||
CCDS IDs: | CCDSCCDS5709.1 CCDS CCDS5710.1 |
Acetylcholinesterase, also known as AChE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq].
Products for ACHE gene
Catalog | Product Name | Application | Company |
GFS:E00715 | acetylcholinesterase; ELISA kit | ELISA | n/a |
GFS:A00715 | acetylcholinesterase; Anti | ANTIBODIES | n/a |
GFS:P00715 | acetylcholinesterase; Protien | Protien | n/a |