Symbol: Name: ID: |
ABI1 abl-interactor 1 GFS:1209 |
Gene name: | ABI1 |
Chromosome: | 10p12.1 |
Previous Symbols: | SSH3BP1 |
Previous Names: | spectrin SH3 domain binding protein 1 |
Aliases: | E3B1, ABI-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104913 | Rat Genome Database ID: | RGD:621008 |
HGNC ID: | HGNC:11320 | RefSeq IDs: | NM_001012750 |
Entrez Gene ID: | 10006 | Ensembl Gene ID: | ENSG00000136754 |
VEGA IDs: | OTTHUMG00000017848 | UniProt ID: | Q8IZP0 |
UCSC ID: | uc001isy.2 | OMIM ID: | 603050 |
Pubmed: | PMID9593709 PMID 9010225 | ||
CCDS IDs: | CCDSCCDS7150.1 CCDS CCDS31169.1 CCDS CCDS31170.1 CCDS CCDS31171.1 |
Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene. The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq].
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity).
Products for ABI1 gene
Catalog | Product Name | Application | Company |
GFS:E01209 | abl-interactor 1; ELISA kit | ELISA | n/a |
GFS:A01209 | abl-interactor 1; Anti | ANTIBODIES | n/a |
GFS:P01209 | abl-interactor 1; Protien | Protien | n/a |