Symbol: Name: ID: |
YAP1 Yes-associated protein 1 GFS:5390 |
Gene name: | YAP1 |
Chromosome: | 11q13 |
Previous Symbols: | |
Previous Names: | Yes-associated protein 1, 65kDa |
Aliases: | YAP65 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103262 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16262 | RefSeq IDs: | NM_001130145 |
Entrez Gene ID: | 10413 | Ensembl Gene ID: | ENSG00000137693 |
VEGA IDs: | UniProt ID: | P46937 | |
UCSC ID: | uc001pgt.2 | OMIM ID: | 606608 |
Pubmed: | PMID7782338 | ||
CCDS IDs: | CCDSCCDS8314.1 CCDS CCDS44716.1 |
65 kDa Yes-associated protein is a protein that in humans is encoded by the YAP1 gene.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008].
Function: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Products for YAP1 gene
Catalog | Product Name | Application | Company |
GFS:E05390 | Yes-associated protein 1; ELISA kit | ELISA | n/a |
GFS:A05390 | Yes-associated protein 1; Anti | ANTIBODIES | n/a |
GFS:P05390 | Yes-associated protein 1; Protien | Protien | n/a |