Symbol: Name: ID: |
YAF2 YY1 associated factor 2 GFS:6442 |
Gene name: | YAF2 |
Chromosome: | 12q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914307 | Rat Genome Database ID: | RGD:1582851 |
HGNC ID: | HGNC:17363 | RefSeq IDs: | NM_001190977 |
Entrez Gene ID: | 10138 | Ensembl Gene ID: | ENSG00000015153 |
VEGA IDs: | UniProt ID: | Q8IY57 | |
UCSC ID: | uc001rmv.2 | OMIM ID: | 607534 |
Pubmed: | PMID9016636 | ||
CCDS IDs: | CCDSCCDS31775.1 |
YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010].
Function: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Products for YAF2 gene
Catalog | Product Name | Application | Company |
GFS:E06442 | YY1 associated factor 2; ELISA kit | ELISA | n/a |
GFS:A06442 | YY1 associated factor 2; Anti | ANTIBODIES | n/a |
GFS:P06442 | YY1 associated factor 2; Protien | Protien | n/a |