Symbol: Name: ID: |
WHSC2 Wolf-Hirschhorn syndrome candidate 2 GFS:2528 |
Gene name: | WHSC2 |
Chromosome: | 4p16.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | NELF-A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1346098 | Rat Genome Database ID: | RGD:1305556 |
HGNC ID: | HGNC:12768 | RefSeq IDs: | NM_005663 |
Entrez Gene ID: | 7469 | Ensembl Gene ID: | ENSG00000185049 |
VEGA IDs: | OTTHUMG00000089967 | UniProt ID: | Q9H3P2 |
UCSC ID: | uc003gem.2 | OMIM ID: | 606026 |
Pubmed: | PMID10409432 | ||
CCDS IDs: | CCDSCCDS3358.2 |
Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
Products for WHSC2 gene
Catalog | Product Name | Application | Company |
GFS:E02528 | Wolf-Hirschhorn syndrome candidate 2; ELISA kit | ELISA | n/a |
GFS:A02528 | Wolf-Hirschhorn syndrome candidate 2; Anti | ANTIBODIES | n/a |
GFS:P02528 | Wolf-Hirschhorn syndrome candidate 2; Protien | Protien | n/a |