Symbol: Name: ID: |
WWOX WW domain containing oxidoreductase GFS:2556 |
Gene name: | WWOX |
Chromosome: | 16q23.3-q24.1 |
Previous Symbols: | |
Previous Names: | WW domain-containing oxidoreductase |
Aliases: | FOR, WOX1, SDR41C1 |
Name Aliases: | short chain dehydrogenase/reductase family 41C, member 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1931237 | Rat Genome Database ID: | RGD:1309927 |
HGNC ID: | HGNC:12799 | RefSeq IDs: | NM_016373 |
Entrez Gene ID: | 51741 | Ensembl Gene ID: | ENSG00000186153 |
VEGA IDs: | UniProt ID: | Q9NZC7 | |
UCSC ID: | uc002ffk.2 | OMIM ID: | 605131 |
Pubmed: | PMID10786676 PMID 10861292 PMID 19027726 | ||
CCDS IDs: | CCDSCCDS42196.1 CCDS CCDS42197.1 |
WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq].
Function: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Products for WWOX gene
Catalog | Product Name | Application | Company |
GFS:E02556 | WW domain containing oxidoreductase; ELISA kit | ELISA | n/a |
GFS:A02556 | WW domain containing oxidoreductase; Anti | ANTIBODIES | n/a |
GFS:P02556 | WW domain containing oxidoreductase; Protien | Protien | n/a |