Symbol: Name: ID: |
WAC WW domain containing adaptor with coiled-coil GFS:6407 |
Gene name: | WAC |
Chromosome: | 10p12.1 |
Previous Symbols: | |
Previous Names: | WW domain-containing adaptor with coiled coil |
Aliases: | Wwp4, FLJ31290, PRO1741, BM-016, MGC10753 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2387357 | Rat Genome Database ID: | |
HGNC ID: | HGNC:17327 | RefSeq IDs: | NM_016628 |
Entrez Gene ID: | 51322 | Ensembl Gene ID: | ENSG00000095787 |
VEGA IDs: | OTTHUMG00000017872 | UniProt ID: | Q9BTA9 |
UCSC ID: | uc001iuf.2 | OMIM ID: | |
Pubmed: | PMID11827461 | ||
CCDS IDs: | CCDSCCDS7159.1 CCDS CCDS7160.1 |
WW domain-containing adapter protein with coiled-coil is a protein that in humans is encoded by the WAC gene.
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
Function: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage.
Products for WAC gene
Catalog | Product Name | Application | Company |
GFS:E06407 | WW domain containing adaptor with coiled-coil; ELISA kit | ELISA | n/a |
GFS:A06407 | WW domain containing adaptor with coiled-coil; Anti | ANTIBODIES | n/a |
GFS:P06407 | WW domain containing adaptor with coiled-coil; Protien | Protien | n/a |