Symbol: Name: ID: |
WEE1 WEE1 homolog (S. pombe) GFS:2522 |
Gene name: | WEE1 |
Chromosome: | 11p15.3-p15.1 |
Previous Symbols: | |
Previous Names: | wee1+ (S. pombe) homolog |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:103075 | Rat Genome Database ID: | RGD:1307895 |
HGNC ID: | HGNC:12761 | RefSeq IDs: | NM_001143976 |
Entrez Gene ID: | 7465 | Ensembl Gene ID: | ENSG00000166483 |
VEGA IDs: | UniProt ID: | P30291 | |
UCSC ID: | uc001mhs.2 | OMIM ID: | 193525 |
Pubmed: | PMID1840647 | ||
CCDS IDs: | CCDSCCDS7800.1 CCDS CCDS44536.1 |
WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq].
Function: May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur.
Products for WEE1 gene
Catalog | Product Name | Application | Company |
GFS:E02522 | WEE1 homolog (S. pombe); ELISA kit | ELISA | n/a |
GFS:A02522 | WEE1 homolog (S. pombe); Anti | ANTIBODIES | n/a |
GFS:P02522 | WEE1 homolog (S. pombe); Protien | Protien | n/a |