Symbol: Name: ID: |
WIPF1 WAS/WASL interacting protein family, member 1 GFS:2505 |
Gene name: | WIPF1 |
Chromosome: | 2q31.2 |
Previous Symbols: | WASPIP |
Previous Names: | Wiskott-Aldrich syndrome protein interacting protein |
Aliases: | WIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2178801 | Rat Genome Database ID: | RGD:620887 |
HGNC ID: | HGNC:12736 | RefSeq IDs: | NM_001077269 |
Entrez Gene ID: | 7456 | Ensembl Gene ID: | ENSG00000115935 |
VEGA IDs: | OTTHUMG00000132334 | UniProt ID: | O43516 |
UCSC ID: | uc002uiz.2 | OMIM ID: | 602357 |
Pubmed: | PMID9405671 | ||
CCDS IDs: | CCDSCCDS2260.1 |
WAS/WASL-interacting protein family member 1 is a protein that in humans is encoded by the WIPF1 gene.
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].
Function: May have direct activity on the actin cytoskeleton. Induces actin polymerization and redistribution. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Products for WIPF1 gene
Catalog | Product Name | Application | Company |
GFS:E02505 | WAS/WASL interacting protein family, member 1; ELISA kit | ELISA | n/a |
GFS:A02505 | WAS/WASL interacting protein family, member 1; Anti | ANTIBODIES | n/a |
GFS:P02505 | WAS/WASL interacting protein family, member 1; Protien | Protien | n/a |