Symbol: Name: ID: |
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) GFS:6756 |
Gene name: | UPF2 |
Chromosome: | 10p14-p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RENT2, DKFZP434D222, KIAA1408, smg-3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2449307 | Rat Genome Database ID: | RGD:1309178 |
HGNC ID: | HGNC:17854 | RefSeq IDs: | NM_015542 |
Entrez Gene ID: | 26019 | Ensembl Gene ID: | ENSG00000151461 |
VEGA IDs: | OTTHUMG00000017678 | UniProt ID: | Q9HAU5 |
UCSC ID: | uc001ilb.2 | OMIM ID: | 605529 |
Pubmed: | PMID11073994 PMID 11113196 | ||
CCDS IDs: | CCDSCCDS7086.1 |
Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008].
Function: Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Binds spliced mRNA.
Products for UPF2 gene
Catalog | Product Name | Application | Company |
GFS:E06756 | UPF2 regulator of nonsense transcripts homolog (yeast); ELISA kit | ELISA | n/a |
GFS:A06756 | UPF2 regulator of nonsense transcripts homolog (yeast); Anti | ANTIBODIES | n/a |
GFS:P06756 | UPF2 regulator of nonsense transcripts homolog (yeast); Protien | Protien | n/a |