| Symbol: Name: ID: |
UGDH UDP-glucose 6-dehydrogenase GFS:2314 |
| Gene name: | UGDH |
| Chromosome: | 4p15.1 |
| Previous Symbols: | |
| Previous Names: | UDP-glucose dehydrogenase |
| Aliases: | |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1306785 | Rat Genome Database ID: | RGD:621879 |
| HGNC ID: | HGNC:12525 | RefSeq IDs: | NM_001184700 |
| Entrez Gene ID: | 7358 | Ensembl Gene ID: | ENSG00000109814 |
| VEGA IDs: | OTTHUMG00000099371 | UniProt ID: | O60701 |
| UCSC ID: | uc003guk.1 | OMIM ID: | 603370 |
| Pubmed: | PMID9737970 PMID 10575217 | ||
| CCDS IDs: | CCDSCCDS3455.1 | ||
UDP-glucose 6-dehydrogenase is an enzyme that in humans is encoded by the UGDH gene.
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Function: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Products for UGDH gene
| Catalog | Product Name | Application | Company |
| GFS:E02314 | UDP-glucose 6-dehydrogenase; ELISA kit | ELISA | n/a |
| GFS:A02314 | UDP-glucose 6-dehydrogenase; Anti | ANTIBODIES | n/a |
| GFS:P02314 | UDP-glucose 6-dehydrogenase; Protien | Protien | n/a |
