Symbol: Name: ID: |
TYROBP TYRO protein tyrosine kinase binding protein GFS:2242 |
Gene name: | TYROBP |
Chromosome: | 19q13.1 |
Previous Symbols: | PLOSL |
Previous Names: | |
Aliases: | DAP12, PLO-SL, KARAP |
Name Aliases: | killer activating receptor associated protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277211 | Rat Genome Database ID: | RGD:1303081 |
HGNC ID: | HGNC:12449 | RefSeq IDs: | NM_001173514 |
Entrez Gene ID: | 7305 | Ensembl Gene ID: | ENSG00000011600 |
VEGA IDs: | UniProt ID: | O43914 | |
UCSC ID: | uc002ocn.2 | OMIM ID: | 604142 |
Pubmed: | PMID9490415 PMID 10888890 | ||
CCDS IDs: | CCDSCCDS12482.1 CCDS CCDS46058.1 |
TYRO protein tyrosine kinase-binding protein is an enzyme that in humans is encoded by the TYROBP gene.
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].
Function: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation.
Products for TYROBP gene
Catalog | Product Name | Application | Company |
GFS:E02242 | TYRO protein tyrosine kinase binding protein; ELISA kit | ELISA | n/a |
GFS:A02242 | TYRO protein tyrosine kinase binding protein; Anti | ANTIBODIES | n/a |
GFS:P02242 | TYRO protein tyrosine kinase binding protein; Protien | Protien | n/a |