Symbol: Name: ID: |
TRIOBP TRIO and F-actin binding protein GFS:6100 |
Gene name: | TRIOBP |
Chromosome: | 22q13.1 |
Previous Symbols: | DFNB28 |
Previous Names: | |
Aliases: | HRIHFB2122, KIAA1662, Tara |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349410 | Rat Genome Database ID: | RGD:1308485 |
HGNC ID: | HGNC:17009 | RefSeq IDs: | NM_001039141 |
Entrez Gene ID: | 11078 | Ensembl Gene ID: | ENSG00000100106 |
VEGA IDs: | OTTHUMG00000150657 | UniProt ID: | Q9H2D6 |
UCSC ID: | uc003atr.2 | OMIM ID: | 609761 |
Pubmed: | PMID11148140 PMID 16385457 PMID 16385458 | ||
CCDS IDs: | CCDSCCDS33644.1 CCDS CCDS43015.1 CCDS CCDS43016.1 |
TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008].
Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
Products for TRIOBP gene
Catalog | Product Name | Application | Company |
GFS:E06100 | TRIO and F-actin binding protein; ELISA kit | ELISA | n/a |
GFS:A06100 | TRIO and F-actin binding protein; Anti | ANTIBODIES | n/a |
GFS:P06100 | TRIO and F-actin binding protein; Protien | Protien | n/a |