Symbol: Name: ID: |
TRADD TNFRSF1A-associated via death domain GFS:1827 |
Gene name: | TRADD |
Chromosome: | 16q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Hs.89862 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109200 | Rat Genome Database ID: | RGD:621313 |
HGNC ID: | HGNC:12030 | RefSeq IDs: | NM_003789 |
Entrez Gene ID: | 8717 | Ensembl Gene ID: | ENSG00000102871 |
VEGA IDs: | OTTHUMG00000137519 | UniProt ID: | Q15628 |
UCSC ID: | uc002eri.1 | OMIM ID: | 603500 |
Pubmed: | PMID7758105 | ||
CCDS IDs: | CCDSCCDS10829.1 |
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Products for TRADD gene
Catalog | Product Name | Application | Company |
GFS:E01827 | TNFRSF1A-associated via death domain; ELISA kit | ELISA | n/a |
GFS:A01827 | TNFRSF1A-associated via death domain; Anti | ANTIBODIES | n/a |
GFS:P01827 | TNFRSF1A-associated via death domain; Protien | Protien | n/a |