Symbol: Name: ID: |
TGIF2 TGFB-induced factor homeobox 2 GFS:4913 |
Gene name: | TGIF2 |
Chromosome: | 20q11.23 |
Previous Symbols: | |
Previous Names: | TGFB-induced factor 2 (TALE family homeobox) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915299 | Rat Genome Database ID: | RGD:1596717 |
HGNC ID: | HGNC:15764 | RefSeq IDs: | NM_001199513 |
Entrez Gene ID: | 60436 | Ensembl Gene ID: | ENSG00000118707 |
VEGA IDs: | OTTHUMG00000032382 | UniProt ID: | Q9GZN2 |
UCSC ID: | uc002xfn.2 | OMIM ID: | 607294 |
Pubmed: | PMID11006116 | ||
CCDS IDs: | CCDSCCDS13278.1 |
Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010].
Function: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Products for TGIF2 gene
Catalog | Product Name | Application | Company |
GFS:E04913 | TGFB-induced factor homeobox 2; ELISA kit | ELISA | n/a |
GFS:A04913 | TGFB-induced factor homeobox 2; Anti | ANTIBODIES | n/a |
GFS:P04913 | TGFB-induced factor homeobox 2; Protien | Protien | n/a |