Symbol: Name: ID: |
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 GFS:1639 |
Gene name: | TINF2 |
Chromosome: | 14q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TIN2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107246 | Rat Genome Database ID: | RGD:1359192 |
HGNC ID: | HGNC:11824 | RefSeq IDs: | NM_001099274 |
Entrez Gene ID: | 26277 | Ensembl Gene ID: | ENSG00000092330 |
VEGA IDs: | UniProt ID: | Q9BSI4 | |
UCSC ID: | uc001woa.3 | OMIM ID: | 604319 |
Pubmed: | PMID10581025 PMID 18252230 | ||
CCDS IDs: | CCDSCCDS41936.1 CCDS CCDS41937.1 |
TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene. This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq].
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.
Products for TINF2 gene
Catalog | Product Name | Application | Company |
GFS:E01639 | TERF1 (TRF1)-interacting nuclear factor 2; ELISA kit | ELISA | n/a |
GFS:A01639 | TERF1 (TRF1)-interacting nuclear factor 2; Anti | ANTIBODIES | n/a |
GFS:P01639 | TERF1 (TRF1)-interacting nuclear factor 2; Protien | Protien | n/a |