Symbol: Name: ID: |
TEK TEK tyrosine kinase, endothelial GFS:1542 |
Gene name: | TEK |
Chromosome: | 9p21 |
Previous Symbols: | VMCM |
Previous Names: | venous malformations, multiple cutaneous and mucosal |
Aliases: | TIE2, TIE-2, VMCM1, CD202b |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98664 | Rat Genome Database ID: | RGD:620980 |
HGNC ID: | HGNC:11724 | RefSeq IDs: | NM_000459 |
Entrez Gene ID: | 7010 | Ensembl Gene ID: | ENSG00000120156 |
VEGA IDs: | OTTHUMG00000019712 | UniProt ID: | Q02763 |
UCSC ID: | uc003zqi.3 | OMIM ID: | 600221 |
Pubmed: | PMID1312667 PMID 7833915 | ||
CCDS IDs: | CCDSCCDS6519.1 |
Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene. The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
Products for TEK gene
Catalog | Product Name | Application | Company |
GFS:E01542 | TEK tyrosine kinase, endothelial; ELISA kit | ELISA | n/a |
GFS:A01542 | TEK tyrosine kinase, endothelial; Anti | ANTIBODIES | n/a |
GFS:P01542 | TEK tyrosine kinase, endothelial; Protien | Protien | n/a |