Symbol: Name: ID: |
TAPBP TAP binding protein (tapasin) GFS:1417 |
Gene name: | TAPBP |
Chromosome: | 6p21.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TAPA |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1201689 | Rat Genome Database ID: | RGD:3819 |
HGNC ID: | HGNC:11566 | RefSeq IDs: | NM_003190 |
Entrez Gene ID: | 6892 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000031090 | UniProt ID: | O15533 |
UCSC ID: | uc003odx.1 | OMIM ID: | 601962 |
Pubmed: | PMID9238042 | ||
CCDS IDs: | CCDSCCDS34426.1 CCDS CCDS34427.1 CCDS CCDS34428.1 |
TAP-associated glycoprotein also known as tapasin or TAPBP is a protein that in humans is encoded by the TAPBP gene. This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq].
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
Products for TAPBP gene
Catalog | Product Name | Application | Company |
GFS:E01417 | TAP binding protein (tapasin); ELISA kit | ELISA | n/a |
GFS:A01417 | TAP binding protein (tapasin); Anti | ANTIBODIES | n/a |
GFS:P01417 | TAP binding protein (tapasin); Protien | Protien | n/a |