Symbol: Name: ID: |
TAOK2 TAO kinase 2 GFS:5922 |
Gene name: | TAOK2 |
Chromosome: | 16p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TAO1, KIAA0881, PSK, PSK1, TAO2, MAP3K17 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915919 | Rat Genome Database ID: | RGD:621590 |
HGNC ID: | HGNC:16835 | RefSeq IDs: | NM_004783 |
Entrez Gene ID: | 9344 | Ensembl Gene ID: | ENSG00000149930 |
VEGA IDs: | OTTHUMG00000132111 | UniProt ID: | Q9UL54 |
UCSC ID: | uc002dva.1 | OMIM ID: | 613199 |
Pubmed: | PMID10048485 PMID 9786855 | ||
CCDS IDs: | CCDSCCDS10662.1 CCDS CCDS10663.1 |
Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.
TAOK2 is a serine/threonine kinase that has a role in cell signaling, microtubule organization and stability, and in apoptosis (Moore et al., 2000 [PubMed 10660600]; Zihni et al., 2007 [PubMed 17158878]).[supplied by OMIM, Dec 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK. Phosphorylates itself, MBP, activated MAPK8 and tubulins. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization (By similarity). Both isoforms are involved in MAPK14 phosphorylation (By similarity).
Products for TAOK2 gene
Catalog | Product Name | Application | Company |
GFS:E05922 | TAO kinase 2; ELISA kit | ELISA | n/a |
GFS:A05922 | TAO kinase 2; Anti | ANTIBODIES | n/a |
GFS:P05922 | TAO kinase 2; Protien | Protien | n/a |