Symbol: Name: ID: |
TCL1A T-cell leukemia/lymphoma 1A GFS:1493 |
Gene name: | TCL1A |
Chromosome: | 14q32.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TCL1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1097166 | Rat Genome Database ID: | RGD:1594686 |
HGNC ID: | HGNC:11648 | RefSeq IDs: | NM_001098725 |
Entrez Gene ID: | 8115 | Ensembl Gene ID: | ENSG00000100721 |
VEGA IDs: | UniProt ID: | P56279 | |
UCSC ID: | uc001yfb.3 | OMIM ID: | 186960 |
Pubmed: | PMID2783489 PMID 7809072 | ||
CCDS IDs: | CCDSCCDS9941.1 |
T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Products for TCL1A gene
Catalog | Product Name | Application | Company |
GFS:E01493 | T-cell leukemia/lymphoma 1A; ELISA kit | ELISA | n/a |
GFS:A01493 | T-cell leukemia/lymphoma 1A; Anti | ANTIBODIES | n/a |
GFS:P01493 | T-cell leukemia/lymphoma 1A; Protien | Protien | n/a |