Symbol: Name: ID: |
SLA2 Src-like-adaptor 2 GFS:6409 |
Gene name: | SLA2 |
Chromosome: | 20q11.23 |
Previous Symbols: | C20orf156 |
Previous Names: | |
Aliases: | FLJ21992, SLAP-2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1925049 | Rat Genome Database ID: | RGD:1562071 |
HGNC ID: | HGNC:17329 | RefSeq IDs: | NM_032214 |
Entrez Gene ID: | 84174 | Ensembl Gene ID: | ENSG00000101082 |
VEGA IDs: | OTTHUMG00000032393 | UniProt ID: | Q9H6Q3 |
UCSC ID: | uc002xfv.2 | OMIM ID: | 606577 |
Pubmed: | PMID11696592 | ||
CCDS IDs: | CCDSCCDS13282.1 CCDS CCDS13283.1 |
Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Products for SLA2 gene
Catalog | Product Name | Application | Company |
GFS:E06409 | Src-like-adaptor 2; ELISA kit | ELISA | n/a |
GFS:A06409 | Src-like-adaptor 2; Anti | ANTIBODIES | n/a |
GFS:P06409 | Src-like-adaptor 2; Protien | Protien | n/a |