Symbol: Name: ID: |
SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) GFS:5876 |
Gene name: | SMG7 |
Chromosome: | 1q25 |
Previous Symbols: | C1orf16 |
Previous Names: | chromosome 1 open reading frame 16 |
Aliases: | KIAA0250, EST1C, SGA56M, SMG-7 |
Name Aliases: | EST1 telomerase component homolog C (S. cerevisiae) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2682334 | Rat Genome Database ID: | RGD:1310761 |
HGNC ID: | HGNC:16792 | RefSeq IDs: | NM_001174061 |
Entrez Gene ID: | 9887 | Ensembl Gene ID: | ENSG00000116698 |
VEGA IDs: | OTTHUMG00000035221 | UniProt ID: | Q92540 |
UCSC ID: | uc001gqg.2 | OMIM ID: | 610964 |
Pubmed: | PMID14636577 PMID 15721257 | ||
CCDS IDs: | CCDSCCDS1355.1 CCDS CCDS41445.1 |
Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011].
Function: Plays a role in nonsense-mediated mRNA decay. Recruits RENT1 to cytoplasmic mRNA decay bodies.
Products for SMG7 gene
Catalog | Product Name | Application | Company |
GFS:E05876 | Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); ELISA kit | ELISA | n/a |
GFS:A05876 | Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); Anti | ANTIBODIES | n/a |
GFS:P05876 | Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); Protien | Protien | n/a |