Symbol: Name: ID: |
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase GFS:1300 |
Gene name: | STUB1 |
Chromosome: | 16p13.3 |
Previous Symbols: | |
Previous Names: | STIP1 homology and U-box containing protein 1 |
Aliases: | NY-CO-7, CHIP, SDCCAG7, HSPABP2, UBOX1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891731 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11427 | RefSeq IDs: | NM_005861 |
Entrez Gene ID: | 10273 | Ensembl Gene ID: | ENSG00000103266 |
VEGA IDs: | OTTHUMG00000121140 | UniProt ID: | Q9UNE7 |
UCSC ID: | uc002cit.2 | OMIM ID: | 607207 |
Pubmed: | PMID10330192 PMID 9610721 | ||
CCDS IDs: | CCDSCCDS10419.1 |
STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene. STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
Products for STUB1 gene
Catalog | Product Name | Application | Company |
GFS:E01300 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; ELISA kit | ELISA | n/a |
GFS:A01300 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; Anti | ANTIBODIES | n/a |
GFS:P01300 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; Protien | Protien | n/a |