Symbol: Name: ID: |
STRADB STE20-related kinase adaptor beta GFS:2865 |
Gene name: | STRADB |
Chromosome: | 2q33.1 |
Previous Symbols: | ALS2CR2 |
Previous Names: | amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 |
Aliases: | CALS-21, PAPK, ILPIPA, ILPIP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2144047 | Rat Genome Database ID: | RGD:1559449 |
HGNC ID: | HGNC:13205 | RefSeq IDs: | NM_018571 |
Entrez Gene ID: | 55437 | Ensembl Gene ID: | ENSG00000082146 |
VEGA IDs: | OTTHUMG00000132831 | UniProt ID: | Q9C0K7 |
UCSC ID: | uc002uyd.3 | OMIM ID: | 607333 |
Pubmed: | PMID11161814 PMID 14511394 | ||
CCDS IDs: | CCDSCCDS2348.1 |
STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Pseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.
Products for STRADB gene
Catalog | Product Name | Application | Company |
GFS:E02865 | STE20-related kinase adaptor beta; ELISA kit | ELISA | n/a |
GFS:A02865 | STE20-related kinase adaptor beta; Anti | ANTIBODIES | n/a |
GFS:P02865 | STE20-related kinase adaptor beta; Protien | Protien | n/a |