Symbol: Name: ID: |
SRPK1 SRSF protein kinase 1 GFS:1197 |
Gene name: | SRPK1 |
Chromosome: | 6p21.31 |
Previous Symbols: | |
Previous Names: | SFRS protein kinase 1 |
Aliases: | SFRSK1 |
Name Aliases: | SR protein kinase 1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:106908 | Rat Genome Database ID: | RGD:1308272 |
HGNC ID: | HGNC:11305 | RefSeq IDs: | NM_003137 |
Entrez Gene ID: | 6732 | Ensembl Gene ID: | ENSG00000096063 |
VEGA IDs: | OTTHUMG00000014583 | UniProt ID: | Q96SB4 |
UCSC ID: | uc003olj.2 | OMIM ID: | 601939 |
Pubmed: | PMID8208298 PMID 10198174 | ||
CCDS IDs: | CCDSCCDS47415.1 |
Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene. This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.
Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
Products for SRPK1 gene
Catalog | Product Name | Application | Company |
GFS:E01197 | SRSF protein kinase 1; ELISA kit | ELISA | n/a |
GFS:A01197 | SRSF protein kinase 1; Anti | ANTIBODIES | n/a |
GFS:P01197 | SRSF protein kinase 1; Protien | Protien | n/a |